Endocrine Abstracts

Anatomical proximity, common blood supply and variability of location of the parathyroid glands make them prone to damage in the course of thyroid gland surgery. Total thyroidectomy (TT) poses a greater risk of postsurgical hypoparathyroidism (hypoPT) than a unilateral lobectomy, and neck lymph nodes dissection is an established risk factor of HypoPT. HypoPT lasting longer than 6–12 months postoperatively is considered permanent. The mechanism responsible for the recover...

GLP-1 receptor agonists have become an important group of drugs used in the treatment of type 2 diabetes and then obesity. There are also many reports of very beneficial effects, e.g. in the treatment of polycystic ovary syndrome. Multidirectional metabolic impact, weight loss, menstrual regularity, and therefore fertility, when used in a group of young women, the possibility of pregnancy should always be taken. We present a case report of the patient which is the starting poi...

The aim of this study was the assessment of diagnostic utility of fine-needle aspiration biopsy needle washout fluids (FNAB-Tg) in the cases of thyroid carcinoma recurrence and analysis of false-positive and false-negative results.Methods: Two hundred and fifteen FNAB-Tg samples from 201 patients with a history of differentiated thyroid carcinoma with suspicious lymph nodes were included in analysis. The wash-out of needle rinsed with 0.5ml of normal sal...

Background: Diagnostic whole-body scan is a standard procedure in patients with thyroid cancer prior to the application of therapeutic dose of 131I. Unfortunately, administration of radioisotope in diagnostic dose may decrease further radioiodine uptake – the phenomenon called ‘thyroid stunning’. We estimated radiation absorbed dose-dependent changes in genetic material, in particular in sodium iodide symporter (NIS) gene promoter, and NIS protein lev...

Introduction: Approximately 5–20% patients treated for differentiated thyroid carcinoma (DTC) develop metastases to the neck lymph nodes. Ultrasound-guided fine-needle aspiration biopsy (FNAB) is a routinely used method in the examination of suspicious lymph nodes. The measurement of thyroglobulin (Tg) levels in needle washout fluids (FNAB-Tg) has been reported to increase the diagnostic accuracy of FNAB.Description of methods/designs: A total of 10...

Objective: The presence of a single parathyroid adenoma is a cause of primary hyperparathyroidism in most cases. Minimally invasive parathyreoidectomy is a treatment of choice in PHPT patients and precise localization of the changed parathyroids is crucial for successful removal.The aim of the study was to assess usefulness of parathormone level estimation in the material obtained during FNAB of the focal neck lesions in order to differentiate structures...

Considering, the pivotal role of DC in formation and development of autoimmunological processes, the investigation of influence of of thyrometabolic status on maturation and function of subtypes of human peripheral blood DC, seems to be reasonable and of particular interest. THE AIM of the present study was a complex analysis of the dendritic cell subsets and fenotypes in patients with chronic thyroiditis (ChT) as well as the patients monitored for differentiated thyroid cance...

Introduction: Chemodectomas of carotid glomus secret mainly catecholamines and/or ACTH. These tumours are very rare cause of ectopic secretion of parathormone (PTH), althought this possibility should be taken into consideration. Therefore, diagnosis of primary hyperparathyroidism (PHPT) as a cause of hypercalcemia in patients with chemodectoma tumours is problematic and may lead to inappropriate diagnosis and treatment. Presented patient is a 64-years old female with non-opera...

Rising thyroglobulin (Tg) serum concentration in patients after total thyroidectomy due to differentiated thyroid cancer (DTC) with no pathological radioiodine uptake on posttherapeutic whole-body scan (WBS) constitutes a challenge for physicians dealing with DTC management.The FDG PET–CT is regarded as a gold diagnostic standard in such cases.Our aim was to find factors which may help predicting positive PET–CT result, a...

Objective: Aiming at the highest specifity in differentiating benign from malignant thyroid nodules effects in new diagnostics developments. Recent technologies such as elastography enable determination of tissue stiffness difference between focal lesions and surrounding thyroid tissue – reference tissue. This method is based on quantifying the stiffness of the lesion – the malignant changes show decreased elasticity when compared to adjacent tissue. Tissue Doppler u...